STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lyeLycopene elongase; Involved in bacterioruberin biosynthesis. Catalyzes the addition of 2 isoprene units to lycopene to generate tetrahydrobisanhydrobacterioruberin. (301 aa)    
Predicted Functional Partners:
crtI
Phytoene dehydrogenase (phytoene desaturase).
 
  
 0.973
HVO_2526
Putative carotenoid biosynthesis protein.
 
   
 0.961
crtB
Phytoene synthase.
 
  
 0.833
idiA
Isopentenyl-diphosphate delta-isomerase, type I.
 
 
 0.747
HVO_2732
FixC family protein.
  
  
 0.600
ubiA2
(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
  
   
 0.597
HVO_2529
Putative oxidoreductase (short-chain dehydrogenase family).
       0.587
hmgA
hydroxymethylglutaryl-CoA reductase (NADPH); Catalyzes the NADPH-dependent reductive deacylation of (S)-3- hydroxy-3-methylglutaryl-CoA (HMG-CoA) to (R)-mevalonate. Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. Is also able to catalyze the reduction of mevaldehyde to mevalonate and the oxidative acylation of mevaldehyde to HMG-CoA.
     
 0.556
fdfT
Squalene synthase.
 
  
 0.501
carB
Carbamoyl-phosphate synthase (glutamine-hydrolyzing) large subunit; Belongs to the CarB family.
      
 0.479
Your Current Organism:
Haloferax volcanii
NCBI taxonomy Id: 309800
Other names: H. volcanii DS2, Haloferax volcanii ATCC 29605, Haloferax volcanii DS2, Haloferax volcanii DSM 3757, Haloferax volcanii str. DS2, Haloferax volcanii strain DS2
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.