STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mvaDPhosphomevalonate decarboxylase; Catalyzes the decarboxylation of mevalonate 5-phosphate (MVAP) to isopentenyl phosphate (IP). Functions in an alternate mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the phosphomevalonate decarboxylase family. (324 aa)    
Predicted Functional Partners:
mvk
Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
 
 
 0.998
HVO_2762
Isopentenyl phosphate kinase; Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
  
  
 0.982
hmgB
hydroxymethylglutaryl-CoA synthase; Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
 
 
 0.948
idiA
Isopentenyl-diphosphate delta-isomerase, type I.
 
 
 0.910
hmgA
hydroxymethylglutaryl-CoA reductase (NADPH); Catalyzes the NADPH-dependent reductive deacylation of (S)-3- hydroxy-3-methylglutaryl-CoA (HMG-CoA) to (R)-mevalonate. Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. Is also able to catalyze the reduction of mevaldehyde to mevalonate and the oxidative acylation of mevaldehyde to HMG-CoA.
 
  
 0.848
idsA1
Bifunctional short chain isoprenyl diphosphate synthase; Belongs to the FPP/GGPP synthase family.
  
 
 0.724
ndh2
Putative NADH dehydrogenase.
       0.612
idsA2
Bifunctional short chain isoprenyl diphosphate synthase; Belongs to the FPP/GGPP synthase family.
  
 
 0.557
crtI
Phytoene dehydrogenase (phytoene desaturase).
     
 0.548
acaB1
acetyl-CoA C-acetyltransferase.
 
  
 0.514
Your Current Organism:
Haloferax volcanii
NCBI taxonomy Id: 309800
Other names: H. volcanii DS2, Haloferax volcanii ATCC 29605, Haloferax volcanii DS2, Haloferax volcanii DSM 3757, Haloferax volcanii str. DS2, Haloferax volcanii strain DS2
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