node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aldH2 | gdhA1 | HVO_1189 | HVO_1451 | Aldehyde dehydrogenase. | Glutamate dehydrogenase (NAD); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.930 |
aldH2 | gdhA2 | HVO_1189 | HVO_1453 | Aldehyde dehydrogenase. | Glutamate dehydrogenase (NADP); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.876 |
aldH2 | glnA | HVO_1189 | HVO_0239 | Aldehyde dehydrogenase. | Glutamine synthetase; Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback- inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation. Under [...] | 0.910 |
aldH2 | proA | HVO_1189 | HVO_1370 | Aldehyde dehydrogenase. | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. | 0.510 |
aldH2 | purQ | HVO_1189 | HVO_2188 | Aldehyde dehydrogenase. | Phosphoribosylformylglycinamidine synthase subunit PurQ; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] | 0.803 |
carA | carB | HVO_2508 | HVO_2361 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing) small subunit; Belongs to the CarA family. | Carbamoyl-phosphate synthase (glutamine-hydrolyzing) large subunit; Belongs to the CarB family. | 0.999 |
carA | glnA | HVO_2508 | HVO_0239 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing) small subunit; Belongs to the CarA family. | Glutamine synthetase; Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback- inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation. Under [...] | 0.958 |
carA | purF | HVO_2508 | HVO_2721 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing) small subunit; Belongs to the CarA family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.976 |
carA | purQ | HVO_2508 | HVO_2188 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing) small subunit; Belongs to the CarA family. | Phosphoribosylformylglycinamidine synthase subunit PurQ; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] | 0.952 |
carB | carA | HVO_2361 | HVO_2508 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing) large subunit; Belongs to the CarB family. | Carbamoyl-phosphate synthase (glutamine-hydrolyzing) small subunit; Belongs to the CarA family. | 0.999 |
carB | glnA | HVO_2361 | HVO_0239 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing) large subunit; Belongs to the CarB family. | Glutamine synthetase; Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback- inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation. Under [...] | 0.960 |
carB | purF | HVO_2361 | HVO_2721 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing) large subunit; Belongs to the CarB family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.989 |
carB | purQ | HVO_2361 | HVO_2188 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing) large subunit; Belongs to the CarB family. | Phosphoribosylformylglycinamidine synthase subunit PurQ; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] | 0.954 |
gdhA1 | aldH2 | HVO_1451 | HVO_1189 | Glutamate dehydrogenase (NAD); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Aldehyde dehydrogenase. | 0.930 |
gdhA1 | gdhA2 | HVO_1451 | HVO_1453 | Glutamate dehydrogenase (NAD); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glutamate dehydrogenase (NADP); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.938 |
gdhA1 | glnA | HVO_1451 | HVO_0239 | Glutamate dehydrogenase (NAD); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glutamine synthetase; Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback- inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation. Under [...] | 0.925 |
gdhA1 | gltB | HVO_1451 | HVO_0869 | Glutamate dehydrogenase (NAD); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glutamate synthase large subunit. | 0.967 |
gdhA1 | nirA1 | HVO_1451 | HVO_1788 | Glutamate dehydrogenase (NAD); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Putative sulfite/nitrite reductase (ferredoxin). | 0.920 |
gdhA1 | proA | HVO_1451 | HVO_1370 | Glutamate dehydrogenase (NAD); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. | 0.839 |
gdhA1 | purQ | HVO_1451 | HVO_2188 | Glutamate dehydrogenase (NAD); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Phosphoribosylformylglycinamidine synthase subunit PurQ; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] | 0.907 |