node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HVO_1734A | hef | HVO_1734A | HVO_3010 | Restriction endonuclease domain protein. | ATP-dependent RNA helicase/nuclease Hef. | 0.733 |
HVO_1734A | mre11 | HVO_1734A | HVO_0853 | Restriction endonuclease domain protein. | DNA double-strand break repair protein Mre11; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity (By similarity). In polyploid organisms, the Rad50/Mre11 complex appears to restrain the repair of double-strand breaks by homologous recombination, allowing another pathway to act as the primary mode of repair. | 0.707 |
HVO_1734A | pcnA | HVO_1734A | HVO_0175 | Restriction endonuclease domain protein. | DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.759 |
HVO_1734A | radA | HVO_1734A | HVO_0104 | Restriction endonuclease domain protein. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assembles on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (Probable). In addition to its role in homologous recombination plays a critical role in maintenance and/or replication of some plasmids, but not in plasmid transformation; Belongs to the eukaryotic RecA-like protein family. | 0.732 |
HVO_1734A | rpa1 | HVO_1734A | HVO_1338 | Restriction endonuclease domain protein. | Replication protein A. | 0.776 |
HVO_1734A | rpa2 | HVO_1734A | HVO_0519 | Restriction endonuclease domain protein. | Replication protein A. | 0.776 |
HVO_1734A | rpa3 | HVO_1734A | HVO_0292 | Restriction endonuclease domain protein. | Replication protein A. | 0.776 |
HVO_1734A | topA | HVO_1734A | HVO_0681 | Restriction endonuclease domain protein. | DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.977 |
hef | HVO_1734A | HVO_3010 | HVO_1734A | ATP-dependent RNA helicase/nuclease Hef. | Restriction endonuclease domain protein. | 0.733 |
hef | pcnA | HVO_3010 | HVO_0175 | ATP-dependent RNA helicase/nuclease Hef. | DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.725 |
hef | polD1 | HVO_3010 | HVO_0003 | ATP-dependent RNA helicase/nuclease Hef. | DNA-directed DNA polymerase D exonuclease subunit DP1; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | 0.508 |
hef | radA | HVO_3010 | HVO_0104 | ATP-dependent RNA helicase/nuclease Hef. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assembles on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (Probable). In addition to its role in homologous recombination plays a critical role in maintenance and/or replication of some plasmids, but not in plasmid transformation; Belongs to the eukaryotic RecA-like protein family. | 0.796 |
hef | rpa1 | HVO_3010 | HVO_1338 | ATP-dependent RNA helicase/nuclease Hef. | Replication protein A. | 0.742 |
hef | rpa2 | HVO_3010 | HVO_0519 | ATP-dependent RNA helicase/nuclease Hef. | Replication protein A. | 0.867 |
hef | rpa3 | HVO_3010 | HVO_0292 | ATP-dependent RNA helicase/nuclease Hef. | Replication protein A. | 0.794 |
hef | topA | HVO_3010 | HVO_0681 | ATP-dependent RNA helicase/nuclease Hef. | DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.706 |
mcm | pcnA | HVO_0220 | HVO_0175 | ATP-dependent DNA helicase MCM; Belongs to the MCM family. | DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.966 |
mcm | polD1 | HVO_0220 | HVO_0003 | ATP-dependent DNA helicase MCM; Belongs to the MCM family. | DNA-directed DNA polymerase D exonuclease subunit DP1; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. | 0.758 |
mcm | radA | HVO_0220 | HVO_0104 | ATP-dependent DNA helicase MCM; Belongs to the MCM family. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assembles on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (Probable). In addition to its role in homologous recombination plays a critical role in maintenance and/or replication of some plasmids, but not in plasmid transformation; Belongs to the eukaryotic RecA-like protein family. | 0.664 |
mcm | rpa1 | HVO_0220 | HVO_1338 | ATP-dependent DNA helicase MCM; Belongs to the MCM family. | Replication protein A. | 0.829 |