STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aglGGlycosyltransferase AglG; Involved in the protein N-glycosylation pathway responsible for the assembly and attachment of an N-linked pentasaccharide that decorates the S-layer glycoprotein and flagellins. Catalyzes the transfer of a glucuronate residue (GlcA) to a glucose residue already bound to a dolichol phosphate (DolP), a compound that serves as a glycan lipid carrier in Archaea. In vitro, is able to add GlcA to DolP-Glc in which the omega-position isoprene is not saturated. However, the likely physiological lipid substrate is alpha,omega-saturated. (313 aa)    
Predicted Functional Partners:
aglB
Dolichyl-monophosphooligosaccharide-protein glycotransferase AglB; Oligosaccharyl transferase (OST) that catalyzes the initial transfer of a defined glycan (a hexose-linked tetrasaccharide composed of a hexose, 2 hexuronic acids and a methyl ester of hexuronic acid in H.volcanii) from the lipid carrier dolichol-monophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (Probable). Involved in the assembly of an N-linked pentasaccharide that decorates the S-layer glycoprotein and flagellins (Pr [...]
     
 0.912
aglI
Glycosyltransferase AglI; Involved in the assembly of a N-linked pentasaccharide that decorates the S-layer glycoprotein and flagellins. Catalyzes the addition to the dolichol phosphate carrier of the hexuronic acid found at position 3 of the pentasaccharide; Belongs to the glycosyltransferase 2 family.
  
   
 0.905
aglE
Glycosyltransferase AglE; Involved in the assembly of a N-linked pentasaccharide that decorates the S-layer glycoprotein and flagellins. Catalyzes the addition to the dolichol phosphate carrier of the hexuronic acid found at position 4 of the pentasaccharide; Belongs to the glycosyltransferase 2 family.
  
   
 0.880
aglJ
Dolichyl-phosphate hexosyltransferase AglJ; Involved in the assembly of a N-linked pentasaccharide that decorates the S-layer glycoprotein and flagellins. Adds the first hexose subunit of the pentasaccharide to the dolichol phosphate carrier; Belongs to the glycosyltransferase 2 family.
 
   
 0.855
aglF
Glucose-1-phosphate uridylyltransferase; Involved in the assembly of a N-linked pentasaccharide that decorates the S-layer glycoprotein and flagellins. Involved in the biosynthesis of the hexuronic acid found at position 3 of the pentasaccharide; Belongs to the UDPGP type 2 family.
  
   
 0.831
aglD
Dolichyl-phosphate mannosyltransferase AglD; Involved in the assembly of a N-linked pentasaccharide that decorates the S-layer glycoprotein and flagellins. Catalyzes the addition of the mannose found at position 5 of the pentasaccharide to its own distinct dolichol phosphate carrier. Belongs to the glycosyltransferase 2 family.
      
 0.775
aglM
UDP-glucose 6-dehydrogenase AglM; Involved in the assembly of a N-linked pentasaccharide that decorates the S-layer glycoprotein and flagellins. Involved in the biosynthesis of the hexuronic acids found at both positions 2 and 3 of the pentasaccharide; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
  
   
 0.774
aglR
Putative flippase AglR; Involved in the assembly of a N-linked pentasaccharide that decorates the S-layer glycoprotein and flagellins. Probably mediates or contributes to the translocation of the dolichol-phosphate-mannose across the membrane; Belongs to the AglR/Agl15 family.
  
   
 0.695
aglP
Hexuronic acid methyltransferase AglP; Involved in the assembly of a N-linked pentasaccharide that decorates the S-layer glycoprotein and flagellins. S-adenosyl-L- methionine-dependent methyltransferase that modifies the hexuronic acid found at position 4 of the pentasaccharide. Belongs to the FkbM methyltransferase family.
  
   
 0.686
csg
S-layer glycoprotein; S-layer protein. The S-layer is a paracrystalline mono- layered assembly of proteins which coat the surface of the cell. Belongs to the halobacterial S-layer protein family.
      
 0.655
Your Current Organism:
Haloferax volcanii
NCBI taxonomy Id: 309800
Other names: H. volcanii DS2, Haloferax volcanii ATCC 29605, Haloferax volcanii DS2, Haloferax volcanii DSM 3757, Haloferax volcanii str. DS2, Haloferax volcanii strain DS2
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