node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
carB | dcd | HVO_2361 | HVO_0661 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing) large subunit; Belongs to the CarB family. | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.797 |
carB | ndk | HVO_2361 | HVO_2740 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing) large subunit; Belongs to the CarB family. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | 0.551 |
carB | tmk | HVO_2361 | HVO_2207 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing) large subunit; Belongs to the CarB family. | Thymidylate kinase. | 0.825 |
dcd | carB | HVO_0661 | HVO_2361 | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | Carbamoyl-phosphate synthase (glutamine-hydrolyzing) large subunit; Belongs to the CarB family. | 0.797 |
dcd | dut | HVO_0661 | HVO_1956 | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | dUTP diphosphatase. | 0.945 |
dcd | hts | HVO_0661 | HVO_2918 | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.914 |
dcd | ndk | HVO_0661 | HVO_2740 | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | 0.930 |
dcd | tmk | HVO_0661 | HVO_2207 | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | Thymidylate kinase. | 0.826 |
dut | dcd | HVO_1956 | HVO_0661 | dUTP diphosphatase. | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.945 |
dut | hts | HVO_1956 | HVO_2918 | dUTP diphosphatase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.933 |
dut | ndk | HVO_1956 | HVO_2740 | dUTP diphosphatase. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | 0.930 |
dut | surE1 | HVO_1956 | HVO_1314 | dUTP diphosphatase. | 5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.905 |
dut | tdk | HVO_1956 | HVO_2891 | dUTP diphosphatase. | Thymidine kinase. | 0.915 |
dut | tmk | HVO_1956 | HVO_2207 | dUTP diphosphatase. | Thymidylate kinase. | 0.930 |
hts | dcd | HVO_2918 | HVO_0661 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.914 |
hts | dut | HVO_2918 | HVO_1956 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | dUTP diphosphatase. | 0.933 |
hts | nrdJ | HVO_2918 | HVO_2452 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.966 |
hts | surE1 | HVO_2918 | HVO_1314 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.924 |
hts | tdk | HVO_2918 | HVO_2891 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | Thymidine kinase. | 0.993 |
hts | tmk | HVO_2918 | HVO_2207 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | Thymidylate kinase. | 0.964 |