trd_0174 protein (Thermomicrobium roseum) - STRING interaction network

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trd_0174

Uncharacterized P-loop hydrolase UPF0079; Identified by match to protein family HMM PF02367; match to protein family HMM TIGR00150. (179 aa)

Predicted Functional Partners:

tsaD

0.999

trd_0175

0.998

trd_0428

0.897

thiL

0.892

trd_0176

0.831

trd_0178

0.796

trd_0173

0.773

trd_0179

0.773

hisA

0.738

hisH

0.737

Your Current Organism:

Thermomicrobium roseum

NCBI taxonomy Id: 309801
Other names: T. roseum DSM 5159, Thermomicrobium roseum DSM 5159

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
hisA	hisH	trd_0181	trd_0180	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007.	Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	0.999
hisA	thiL	trd_0181	trd_0172	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007.	Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.	0.626
hisA	trd_0173	trd_0181	trd_0173	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007.	glutamyl-tRNA(Gln) amidotransferase subunit A; Identified by match to protein family HMM PF01425; Belongs to the amidase family.	0.741
hisA	trd_0174	trd_0181	trd_0174	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007.	Uncharacterized P-loop hydrolase UPF0079; Identified by match to protein family HMM PF02367; match to protein family HMM TIGR00150.	0.738
hisA	trd_0175	trd_0181	trd_0175	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007.	Putative glycoprotease family; Identified by match to protein family HMM PF00814.	0.760
hisA	trd_0176	trd_0181	trd_0176	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007.	Ribosomal-protein-alanine acetyltransferase; Identified by match to protein family HMM PF00583; match to protein family HMM TIGR01575.	0.740
hisA	trd_0178	trd_0181	trd_0178	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007.	Inositol-1-monophosphatase; Identified by match to protein family HMM PF00459; Belongs to the inositol monophosphatase superfamily.	0.852
hisA	trd_0179	trd_0181	trd_0179	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007.	Identified by match to protein family HMM PF00850.	0.777
hisA	tsaD	trd_0181	trd_0177	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007.	O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family.	0.767
hisH	hisA	trd_0180	trd_0181	Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007.	0.999
hisH	thiL	trd_0180	trd_0172	Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.	0.586
hisH	trd_0173	trd_0180	trd_0173	Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	glutamyl-tRNA(Gln) amidotransferase subunit A; Identified by match to protein family HMM PF01425; Belongs to the amidase family.	0.740
hisH	trd_0174	trd_0180	trd_0174	Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	Uncharacterized P-loop hydrolase UPF0079; Identified by match to protein family HMM PF02367; match to protein family HMM TIGR00150.	0.737
hisH	trd_0175	trd_0180	trd_0175	Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	Putative glycoprotease family; Identified by match to protein family HMM PF00814.	0.785
hisH	trd_0176	trd_0180	trd_0176	Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	Ribosomal-protein-alanine acetyltransferase; Identified by match to protein family HMM PF00583; match to protein family HMM TIGR01575.	0.737
hisH	trd_0178	trd_0180	trd_0178	Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	Inositol-1-monophosphatase; Identified by match to protein family HMM PF00459; Belongs to the inositol monophosphatase superfamily.	0.823
hisH	trd_0179	trd_0180	trd_0179	Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	Identified by match to protein family HMM PF00850.	0.762
hisH	tsaD	trd_0180	trd_0177	Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family.	0.737
thiL	hisA	trd_0172	trd_0181	Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007.	0.626
thiL	hisH	trd_0172	trd_0180	Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.	Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	0.586