metX protein (Thermomicrobium roseum) - STRING interaction network

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[Homology]

Score

metX

Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (414 aa)

Predicted Functional Partners:

trd_0367

0.993

trd_0006

0.836

glyA

0.831

trpB

0.801

trpA

0.800

trd_1049

0.569

trd_0392

0.565

trd_0369

0.430

trd_0370

0.430

Your Current Organism:

Thermomicrobium roseum

NCBI taxonomy Id: 309801
Other names: T. roseum DSM 5159, Thermomicrobium roseum DSM 5159

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
glyA	metX	trd_0755	trd_0368	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.	0.831
glyA	trd_0006	trd_0755	trd_0006	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Threonine ammonia-lyase, biosynthetic; Identified by match to protein family HMM PF00291.	0.923
glyA	trd_1049	trd_0755	trd_1049	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	5-methyltetrahydrofolate S-homocysteine methyltransferase; Identified by match to protein family HMM PF02219; match to protein family HMM PF02574.	0.951
glyA	trpA	trd_0755	trd_0108	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.926
glyA	trpB	trd_0755	trd_0107	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.923
metX	glyA	trd_0368	trd_0755	Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.831
metX	trd_0006	trd_0368	trd_0006	Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.	Threonine ammonia-lyase, biosynthetic; Identified by match to protein family HMM PF00291.	0.836
metX	trd_0367	trd_0368	trd_0367	Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.	Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF03447.	0.993
metX	trd_0369	trd_0368	trd_0369	Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.	Putative AttH.	0.430
metX	trd_0370	trd_0368	trd_0370	Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.	Putative membrane protein mmpL3; Identified by match to protein family HMM PF03176.	0.430
metX	trd_0392	trd_0368	trd_0392	Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.	Methionine gamma-lyase; Identified by match to protein family HMM PF01053; match to protein family HMM PF01212.	0.565
metX	trd_1049	trd_0368	trd_1049	Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.	5-methyltetrahydrofolate S-homocysteine methyltransferase; Identified by match to protein family HMM PF02219; match to protein family HMM PF02574.	0.569
metX	trpA	trd_0368	trd_0108	Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.	Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.800
metX	trpB	trd_0368	trd_0107	Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.	Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.801
trd_0006	glyA	trd_0006	trd_0755	Threonine ammonia-lyase, biosynthetic; Identified by match to protein family HMM PF00291.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.923
trd_0006	metX	trd_0006	trd_0368	Threonine ammonia-lyase, biosynthetic; Identified by match to protein family HMM PF00291.	Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.	0.836
trd_0006	trd_0367	trd_0006	trd_0367	Threonine ammonia-lyase, biosynthetic; Identified by match to protein family HMM PF00291.	Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF03447.	0.509
trd_0006	trd_1049	trd_0006	trd_1049	Threonine ammonia-lyase, biosynthetic; Identified by match to protein family HMM PF00291.	5-methyltetrahydrofolate S-homocysteine methyltransferase; Identified by match to protein family HMM PF02219; match to protein family HMM PF02574.	0.897
trd_0006	trpA	trd_0006	trd_0108	Threonine ammonia-lyase, biosynthetic; Identified by match to protein family HMM PF00291.	Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.923
trd_0006	trpB	trd_0006	trd_0107	Threonine ammonia-lyase, biosynthetic; Identified by match to protein family HMM PF00291.	Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.940