STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trd_1606Dolichyl-phosphate mannose synthase related protein; Identified by match to protein family HMM PF00535. (240 aa)    
Predicted Functional Partners:
trd_1607
Transcriptional repressor; Identified by match to protein family HMM PF00480.
       0.773
hslV
Heat shock protein HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
  
    0.719
hslU
Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.
       0.714
trd_1609
Putative dipeptide ABC transporter dipeptide-binding protein; Identified by match to protein family HMM PF00496.
       0.714
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
       0.557
trd_1602
Mannose-1-phosphate guanylyltransferase (GDP); Identified by match to protein family HMM PF00483.
  
  
 0.496
trd_1601
Probable smf protein; Identified by match to protein family HMM PF02481; match to protein family HMM TIGR00732.
       0.458
trd_1801
Putative membrane protein.
 
  
 0.437
Your Current Organism:
Thermomicrobium roseum
NCBI taxonomy Id: 309801
Other names: T. roseum DSM 5159, Thermomicrobium roseum DSM 5159
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