STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (406 aa)    
Predicted Functional Partners:
trpC
Indole-3-glycerol phosphate synthase; Identified by match to protein family HMM PF00218; Belongs to the TrpC family.
 
 0.999
trpF
N-(5'phosphoribosyl)anthranilate isomerase; Identified by match to protein family HMM PF00697; Belongs to the TrpF family.
  
 0.999
trpA
Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 0.999
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
  
 0.994
SRU_1665
Para-aminobenzoate/anthranilate synthase glutamine amidotransferasecomponent II; Identified by match to protein family HMM PF00117; match to protein family HMM TIGR00566.
  
 0.975
ilvA-2
Threonine dehydratase; Identified by match to protein family HMM PF00291; match to protein family HMM PF01842; match to protein family HMM TIGR01127.
  
 0.934
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.928
SRU_1123
Cystathionine beta-synthase; Identified by match to protein family HMM PF00291; match to protein family HMM PF00571; match to protein family HMM TIGR01137.
    
 0.910
SRU_2787
Cysteine synthase B; Identified by match to protein family HMM PF00291.
     
 0.905
SRU_0962
Phosphatidylserine synthase; Identified by match to protein family HMM PF01066; match to protein family HMM TIGR00473; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
     
  0.900
Your Current Organism:
Salinibacter ruber
NCBI taxonomy Id: 309807
Other names: S. ruber DSM 13855, Salinibacter ruber DSM 13855, Salinibacter ruber str. DSM 13855, Salinibacter ruber strain DSM 13855
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