STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
coxA1Cytochrome oxidase subunit I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (581 aa)    
Predicted Functional Partners:
coxB2
Cytochrome c oxidase subunit II; Identified by similarity to GB:AAV46104.1; match to protein family HMM PF00116.
 
 0.999
SRU_2098
Conserved hypothetical protein.
 0.999
coxB1
Cytochrome oxidase subunit II; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
 0.999
cyoE
Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
 
 0.995
SRU_2097
Caa(3)-type oxidase, subunit IV subfamily, putative; Identified by match to protein family HMM TIGR02229.
 
  
  0.984
nuoM
NADH dehydrogenase i, m subunit; Identified by match to protein family HMM PF00361; match to protein family HMM TIGR01972.
  
 
 0.945
coxA2
Cytochrome c oxidase subunit I; Identified by similarity to GB:AAV46105.1; match to protein family HMM PF00115.
  
  
0.943
nuoH
NADH dehydrogenase i, h subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
  
 
 0.934
SRU_0323
Cytochrome c oxidase, cbb3-type, subunit II; Identified by match to protein family HMM PF02433.
    
 0.911
SRU_0322
Putative cytochrome-c oxidase; Identified by match to protein family HMM PF00115.
    
 0.909
Your Current Organism:
Salinibacter ruber
NCBI taxonomy Id: 309807
Other names: S. ruber DSM 13855, Salinibacter ruber DSM 13855, Salinibacter ruber str. DSM 13855, Salinibacter ruber strain DSM 13855
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