node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SRU_1477 | ilvD | SRU_1477 | SRU_2153 | Aconitate hydratase, putative; Identified by match to protein family HMM PF00330; match to protein family HMM PF00694; match to protein family HMM TIGR01342. | Dihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family. | 0.407 |
SRU_1477 | leuB | SRU_1477 | SRU_2148 | Aconitate hydratase, putative; Identified by match to protein family HMM PF00330; match to protein family HMM PF00694; match to protein family HMM TIGR01342. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.910 |
SRU_2146 | SRU_2154 | SRU_2146 | SRU_2154 | Acetolactate synthase small subunit; Identified by match to protein family HMM PF01842; match to protein family HMM TIGR00119. | 2-isopropylmalate synthase/homocitrate synthase family protein; Identified by match to protein family HMM PF00682; match to protein family HMM TIGR00977; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.941 |
SRU_2146 | ilvA-2 | SRU_2146 | SRU_2287 | Acetolactate synthase small subunit; Identified by match to protein family HMM PF01842; match to protein family HMM TIGR00119. | Threonine dehydratase; Identified by match to protein family HMM PF00291; match to protein family HMM PF01842; match to protein family HMM TIGR01127. | 0.964 |
SRU_2146 | ilvB | SRU_2146 | SRU_2145 | Acetolactate synthase small subunit; Identified by match to protein family HMM PF01842; match to protein family HMM TIGR00119. | Acetolactate synthase, large subunit, biosynthetic type; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR00118. | 0.999 |
SRU_2146 | ilvC | SRU_2146 | SRU_2147 | Acetolactate synthase small subunit; Identified by match to protein family HMM PF01842; match to protein family HMM TIGR00119. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |
SRU_2146 | ilvD | SRU_2146 | SRU_2153 | Acetolactate synthase small subunit; Identified by match to protein family HMM PF01842; match to protein family HMM TIGR00119. | Dihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family. | 0.933 |
SRU_2146 | leuA | SRU_2146 | SRU_2149 | Acetolactate synthase small subunit; Identified by match to protein family HMM PF01842; match to protein family HMM TIGR00119. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.971 |
SRU_2146 | leuB | SRU_2146 | SRU_2148 | Acetolactate synthase small subunit; Identified by match to protein family HMM PF01842; match to protein family HMM TIGR00119. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.990 |
SRU_2146 | leuC | SRU_2146 | SRU_2150 | Acetolactate synthase small subunit; Identified by match to protein family HMM PF01842; match to protein family HMM TIGR00119. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.897 |
SRU_2146 | leuD | SRU_2146 | SRU_2152 | Acetolactate synthase small subunit; Identified by match to protein family HMM PF01842; match to protein family HMM TIGR00119. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.895 |
SRU_2154 | SRU_2146 | SRU_2154 | SRU_2146 | 2-isopropylmalate synthase/homocitrate synthase family protein; Identified by match to protein family HMM PF00682; match to protein family HMM TIGR00977; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Acetolactate synthase small subunit; Identified by match to protein family HMM PF01842; match to protein family HMM TIGR00119. | 0.941 |
SRU_2154 | ilvB | SRU_2154 | SRU_2145 | 2-isopropylmalate synthase/homocitrate synthase family protein; Identified by match to protein family HMM PF00682; match to protein family HMM TIGR00977; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Acetolactate synthase, large subunit, biosynthetic type; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR00118. | 0.903 |
SRU_2154 | ilvC | SRU_2154 | SRU_2147 | 2-isopropylmalate synthase/homocitrate synthase family protein; Identified by match to protein family HMM PF00682; match to protein family HMM TIGR00977; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.747 |
SRU_2154 | ilvD | SRU_2154 | SRU_2153 | 2-isopropylmalate synthase/homocitrate synthase family protein; Identified by match to protein family HMM PF00682; match to protein family HMM TIGR00977; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Dihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family. | 0.987 |
SRU_2154 | leuA | SRU_2154 | SRU_2149 | 2-isopropylmalate synthase/homocitrate synthase family protein; Identified by match to protein family HMM PF00682; match to protein family HMM TIGR00977; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.925 |
SRU_2154 | leuB | SRU_2154 | SRU_2148 | 2-isopropylmalate synthase/homocitrate synthase family protein; Identified by match to protein family HMM PF00682; match to protein family HMM TIGR00977; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.739 |
SRU_2154 | leuC | SRU_2154 | SRU_2150 | 2-isopropylmalate synthase/homocitrate synthase family protein; Identified by match to protein family HMM PF00682; match to protein family HMM TIGR00977; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.976 |
SRU_2154 | leuD | SRU_2154 | SRU_2152 | 2-isopropylmalate synthase/homocitrate synthase family protein; Identified by match to protein family HMM PF00682; match to protein family HMM TIGR00977; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.990 |
ilvA-2 | SRU_2146 | SRU_2287 | SRU_2146 | Threonine dehydratase; Identified by match to protein family HMM PF00291; match to protein family HMM PF01842; match to protein family HMM TIGR01127. | Acetolactate synthase small subunit; Identified by match to protein family HMM PF01842; match to protein family HMM TIGR00119. | 0.964 |