Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
cblbCbl proto-oncogene B, E3 ubiquitin protein ligase. (949 aa)    
Predicted Functional Partners:
syk
Tyrosine-protein kinase.
    
 0.980
LOC101073748
Receptor protein-tyrosine kinase.
    
 0.973
rapgef1
Rap guanine nucleotide exchange factor (GEF) 1b.
   
 0.973
egfr
Receptor protein-tyrosine kinase.
    
 0.973
SH2B2
SH2B adaptor protein 2.
    
 0.970
cbl
Cbl proto-oncogene, E3 ubiquitin protein ligase.
  
 
 
0.957
LOC101070370
Uncharacterized protein.
  
 
 
0.956
sh3kbp1
SH3-domain kinase binding protein 1.
    
 0.954
LOC101074430
Tyrosine-protein kinase receptor.
    
 0.929
LOC101074083
Tyrosine-protein kinase receptor.
    
 0.929
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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