STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC101061156Cdk5 and Abl enzyme substrate 2b; Belongs to the cyclin family. (524 aa)    
Predicted Functional Partners:
cdk5
Cyclin-dependent kinase 5.
    
 0.849
fibp
Fibroblast growth factor (acidic) intracellular binding protein a.
    
 
 0.650
DLK1
Delta like non-canonical Notch ligand 1.
    
   0.623
ccna2
Cyclin A2; Belongs to the cyclin family.
     
 0.554
ccna1
Cyclin-A1 isoform X1.
     
 0.554
LOC101079595
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 
 0.535
LOC101072140
Cyclin dependent kinase 18.
   
 0.503
LOC101071662
Wee1-like protein kinase.
     
 0.502
wee1
Wee1-like protein kinase.
     
 0.502
LOC101064374
Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.
   
 0.482
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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