casc3 protein (Takifugu rubripes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

casc3

Casc3 exon junction complex subunit. (740 aa)

Predicted Functional Partners:

eif4a3

0.985

UPF2

0.984

rbm8a

0.980

LOC101074452

0.977

pym1

0.937

LOC101064659

0.930

UPF1

0.930

upf3b

0.911

pnn

0.883

upf3a

0.881

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101064659	LOC101074452	ENSTRUP00000000308	ENSTRUP00000078039	Uncharacterized protein.	Mago homolog, exon junction complex subunit.	0.927
LOC101064659	UPF1	ENSTRUP00000000308	ENSTRUP00000012294	Uncharacterized protein.	Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).	0.900
LOC101064659	UPF2	ENSTRUP00000000308	ENSTRUP00000018623	Uncharacterized protein.	UPF2 regulator of nonsense mediated mRNA decay.	0.998
LOC101064659	casc3	ENSTRUP00000000308	ENSTRUP00000001608	Uncharacterized protein.	Casc3 exon junction complex subunit.	0.930
LOC101064659	eif4a3	ENSTRUP00000000308	ENSTRUP00000029160	Uncharacterized protein.	Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family.	0.971
LOC101064659	pym1	ENSTRUP00000000308	ENSTRUP00000075262	Uncharacterized protein.	PYM homolog 1, exon junction complex associated factor.	0.425
LOC101064659	rbm8a	ENSTRUP00000000308	ENSTRUP00000033509	Uncharacterized protein.	RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.	0.966
LOC101064659	upf3a	ENSTRUP00000000308	ENSTRUP00000073483	Uncharacterized protein.	UPF3A regulator of nonsense mediated mRNA decay.	0.983
LOC101064659	upf3b	ENSTRUP00000000308	ENSTRUP00000026872	Uncharacterized protein.	UPF3B regulator of nonsense mediated mRNA decay.	0.993
LOC101074452	LOC101064659	ENSTRUP00000078039	ENSTRUP00000000308	Mago homolog, exon junction complex subunit.	Uncharacterized protein.	0.927
LOC101074452	UPF1	ENSTRUP00000078039	ENSTRUP00000012294	Mago homolog, exon junction complex subunit.	Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).	0.923
LOC101074452	UPF2	ENSTRUP00000078039	ENSTRUP00000018623	Mago homolog, exon junction complex subunit.	UPF2 regulator of nonsense mediated mRNA decay.	0.985
LOC101074452	casc3	ENSTRUP00000078039	ENSTRUP00000001608	Mago homolog, exon junction complex subunit.	Casc3 exon junction complex subunit.	0.977
LOC101074452	eif4a3	ENSTRUP00000078039	ENSTRUP00000029160	Mago homolog, exon junction complex subunit.	Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family.	0.995
LOC101074452	pnn	ENSTRUP00000078039	ENSTRUP00000082108	Mago homolog, exon junction complex subunit.	Pinin, desmosome associated protein.	0.972
LOC101074452	pym1	ENSTRUP00000078039	ENSTRUP00000075262	Mago homolog, exon junction complex subunit.	PYM homolog 1, exon junction complex associated factor.	0.976
LOC101074452	rbm8a	ENSTRUP00000078039	ENSTRUP00000033509	Mago homolog, exon junction complex subunit.	RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.	0.999
LOC101074452	upf3a	ENSTRUP00000078039	ENSTRUP00000073483	Mago homolog, exon junction complex subunit.	UPF3A regulator of nonsense mediated mRNA decay.	0.927
LOC101074452	upf3b	ENSTRUP00000078039	ENSTRUP00000026872	Mago homolog, exon junction complex subunit.	UPF3B regulator of nonsense mediated mRNA decay.	0.963
UPF1	LOC101064659	ENSTRUP00000012294	ENSTRUP00000000308	Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).	Uncharacterized protein.	0.900