mrpl2 protein (Takifugu rubripes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

mrpl2

Mitochondrial ribosomal protein L2. (310 aa)

Predicted Functional Partners:

rpl23

0.999

Mrpl21

0.998

mrpl19

0.998

fau

0.998

ENSTRUP00000047893

0.998

mrpl22

0.998

mrpl17

0.998

mrps16

0.998

mrpl27

0.998

mrpl20

0.998

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSTRUP00000047893	Mrpl21	ENSTRUP00000047893	ENSTRUP00000015393	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	Uncharacterized protein.	0.999
ENSTRUP00000047893	mrpl17	ENSTRUP00000047893	ENSTRUP00000059125	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	Mitochondrial ribosomal protein L17.	0.999
ENSTRUP00000047893	mrpl19	ENSTRUP00000047893	ENSTRUP00000018050	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	Mitochondrial ribosomal protein L19.	0.999
ENSTRUP00000047893	mrpl2	ENSTRUP00000047893	ENSTRUP00000002152	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	Mitochondrial ribosomal protein L2.	0.998
ENSTRUP00000047893	mrpl20	ENSTRUP00000047893	ENSTRUP00000079172	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	Mitochondrial ribosomal protein L20; Belongs to the bacterial ribosomal protein bL20 family.	0.999
ENSTRUP00000047893	mrpl22	ENSTRUP00000047893	ENSTRUP00000053361	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	Mitochondrial ribosomal protein L22; Belongs to the universal ribosomal protein uL22 family.	0.997
ENSTRUP00000047893	mrpl27	ENSTRUP00000047893	ENSTRUP00000078103	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	Mitochondrial ribosomal protein L27.	0.998
ENSTRUP00000047893	mrps16	ENSTRUP00000047893	ENSTRUP00000071946	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	Mitochondrial ribosomal protein S16.	0.999
ENSTRUP00000047893	rpl23	ENSTRUP00000047893	ENSTRUP00000065488	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	Ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family.	0.999
Mrpl21	ENSTRUP00000047893	ENSTRUP00000015393	ENSTRUP00000047893	Uncharacterized protein.	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	0.999
Mrpl21	mrpl17	ENSTRUP00000015393	ENSTRUP00000059125	Uncharacterized protein.	Mitochondrial ribosomal protein L17.	0.999
Mrpl21	mrpl19	ENSTRUP00000015393	ENSTRUP00000018050	Uncharacterized protein.	Mitochondrial ribosomal protein L19.	0.999
Mrpl21	mrpl2	ENSTRUP00000015393	ENSTRUP00000002152	Uncharacterized protein.	Mitochondrial ribosomal protein L2.	0.998
Mrpl21	mrpl20	ENSTRUP00000015393	ENSTRUP00000079172	Uncharacterized protein.	Mitochondrial ribosomal protein L20; Belongs to the bacterial ribosomal protein bL20 family.	0.999
Mrpl21	mrpl22	ENSTRUP00000015393	ENSTRUP00000053361	Uncharacterized protein.	Mitochondrial ribosomal protein L22; Belongs to the universal ribosomal protein uL22 family.	0.998
Mrpl21	mrpl27	ENSTRUP00000015393	ENSTRUP00000078103	Uncharacterized protein.	Mitochondrial ribosomal protein L27.	0.999
Mrpl21	mrps16	ENSTRUP00000015393	ENSTRUP00000071946	Uncharacterized protein.	Mitochondrial ribosomal protein S16.	0.999
Mrpl21	rpl23	ENSTRUP00000015393	ENSTRUP00000065488	Uncharacterized protein.	Ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family.	0.999
fau	mrpl2	ENSTRUP00000029977	ENSTRUP00000002152	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	Mitochondrial ribosomal protein L2.	0.998
fau	mrpl22	ENSTRUP00000029977	ENSTRUP00000053361	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	Mitochondrial ribosomal protein L22; Belongs to the universal ribosomal protein uL22 family.	0.999

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.851

expected number of edges:

12

PPI enrichment p-value:

2.36e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006260

DNA replication

5 of 19

1.86

2.31

8.40e-06

GO:0006259

DNA metabolic process

6 of 124

1.13

1.0

0.00066

GO:0090304

Nucleic acid metabolic process

8 of 269

0.92

0.83

0.00026

GO:0006281

DNA repair

3 of 39

1.33

0.72

0.0243

GO:0044260

Cellular macromolecule metabolic process

7 of 296

0.82

0.62

0.0033

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140097

Catalytic activity, acting on DNA

6 of 66

1.4

1.66

1.45e-05

GO:0003887

DNA-directed DNA polymerase activity

3 of 7

2.08

1.62

0.00069

GO:0140640

Catalytic activity, acting on a nucleic acid

8 of 145

1.19

1.43

2.35e-06

GO:0003911

DNA ligase (NAD+) activity

2 of 2

2.44

1.17

0.0071

GO:0004527

Exonuclease activity

2 of 10

1.75

0.71

0.0430

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009360

DNA polymerase III complex

2 of 2

2.44

1.13

0.0083

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1421

DNA replication, and Sigma-70 region 3

7 of 11

2.25

5.31

2.89e-12

CL:1418

Mixed, incl. DNA replication, and ATP-dependent activity, acting on DNA

9 of 38

1.82

4.24

6.26e-13

CL:1424

DNA polymerase complex, and WYL domain

5 of 5

2.44

4.23

4.81e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03030

DNA replication

7 of 20

1.99

4.24

6.44e-11

map03430

Mismatch repair

7 of 21

1.97

4.18

6.44e-11

map03440

Homologous recombination

5 of 30

1.67

2.25

2.40e-06

map03410

Base excision repair

2 of 8

1.84

0.94

0.0148

map03420

Nucleotide excision repair

2 of 12

1.67

0.81

0.0238

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009360

DNA polymerase III complex

2 of 2

2.44

0.97

0.0166

GOCC:0061695

Transferase complex, transferring phosphorus-containing groups

3 of 39

1.33

0.76

0.0194

GOCC:1902494

Catalytic complex

5 of 141

0.99

0.62

0.0166

GOCC:0032991

Protein-containing complex

6 of 335

0.7

0.45

0.0202

GOCC:0005622

Intracellular

9 of 854

0.47

0.33

0.0194

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036397

Ribonuclease H superfamily

3 of 11

1.88

0.98

0.0127

IPR036420

BRCT domain superfamily

2 of 2

2.44

0.88

0.0243

IPR001357

BRCT domain

2 of 2

2.44

0.88

0.0243

IPR012337

Ribonuclease H-like superfamily

3 of 18

1.67

0.82

0.0230

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (18%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About