Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ptch2Patched 2. (1308 aa)    
Predicted Functional Partners:
smo
Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.998
shh
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
   
 0.997
LOC101066095
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
   
 0.992
dhh
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
   
 0.990
cdon
Cell adhesion associated, oncogene regulated.
    
 0.990
boc
BOC cell adhesion associated, oncogene regulated.
    
 0.983
SMURF2
E3 ubiquitin-protein ligase.
    
 0.975
LOC101071114
E3 ubiquitin-protein ligase.
    
 0.975
SMURF1
SMAD specific E3 ubiquitin protein ligase 1.
    
 0.975
H2SAC3_TAKRU
Growth arrest-specific 1a.
     
 0.968
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
Server load: low (22%) [HD]