Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
bace2Beta-secretase 2; Belongs to the peptidase A1 family. (506 aa)    
Predicted Functional Partners:
LOC101078447
Amyloid-beta A4 protein; Functional neuronal receptor which couples to intracellular signaling pathway through the GTP-binding protein G(O); Belongs to the APP family.
    
 0.888
APP
Amyloid beta precursor protein.
    
 0.851
aplp2
Amyloid beta (A4) precursor-like protein 2.
    
 0.732
GGA1
Golgi associated, gamma adaptin ear containing, ARF binding protein 1.
    
 0.678
LOC101078557
Uncharacterized protein.
    
 0.678
LOC101074958
Uncharacterized protein.
    
 0.678
aplp1
Amyloid beta (A4) precursor-like protein 1.
    
 0.660
LOC101078322
Furin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family.
    
 0.647
LOC101061571
Furin (paired basic amino acid cleaving enzyme) b; Belongs to the peptidase S8 family.
    
 0.647
sez6l
Seizure related 6 homolog (mouse)-like.
    
 0.622
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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