Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-expression
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[Homology]
Score
RNF5RING-type domain-containing protein. (223 aa)    
Predicted Functional Partners:
rnf185
Ring finger protein 185.
  
  
 
0.903
cftr
Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.
    
 0.887
tmub1
Transmembrane and ubiquitin-like domain containing 1.
    
 
 0.851
LOC101067994
ER lipid raft associated 1.
   
 0.845
LOC101072418
Cholesterol 25-hydroxylase like 3.
   
 0.845
sel1l
SEL1L adaptor subunit of ERAD E3 ubiquitin ligase.
   
 
 0.844
derl2
Derlin-2/3.
    
 0.814
tmem259
Transmembrane protein 259.
    
 
 0.730
rps27a
Ribosomal protein S27a.
    
  0.714
uba52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
    
 0.700
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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