Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
pou4f2POU domain protein. (382 aa)    
Predicted Functional Partners:
VSX2
Visual system homeobox 2.
   
  
 0.754
atoh7
Atonal bHLH transcription factor 7.
    
 
 0.748
vsx1
Visual system homeobox 1 homolog, chx10-like.
   
  
 0.596
Barhl2
BarH-like homeobox 2.
  
  
 0.592
LOC101066300
Opsin 4.1.
      
 0.578
LOC101079595
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
     
  0.546
sncg
Gamma-synuclein; Belongs to the synuclein family.
      
 0.519
neurod1
Neurogenic differentiation factor.
   
  
 0.516
LOC101072423
RNA binding protein, mRNA processing factor.
      
 0.516
NR2E3
Nuclear receptor subfamily 2 group E member 3.
    
 
 0.501
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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