STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ptgs2Prostaglandin-endoperoxide synthase 2b. (617 aa)    
Predicted Functional Partners:
LOC101079595
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 
 0.975
PTGS1
Prostaglandin-endoperoxide synthase 1.
  
 
0.971
LOC101070781
Prostaglandin-endoperoxide synthase 1.
  
 
0.971
ptges
Prostaglandin E synthase.
     
 0.970
ptges2
Prostaglandin E synthase 2-like.
     
 0.954
pla2g4a
Phospholipase A2.
  
 
 0.938
prxl2b
Peroxiredoxin like 2B.
     
 0.934
ptges3
Prostaglandin E synthase 3b (cytosolic).
     
 0.934
LOC101068061
Prostaglandin E synthase 3a (cytosolic).
     
 0.934
LOC101069230
Prostaglandin I2 (prostacyclin) synthase; Belongs to the cytochrome P450 family.
    
 0.929
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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