zc3h15 protein (Takifugu rubripes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

zc3h15

Zinc finger CCCH-type containing 15. (423 aa)

Predicted Functional Partners:

drg1

0.993

drg2

0.955

fau

0.857

dnajc2

0.803

rpl23a

0.794

rps15

0.794

rwdd1

0.787

rps12

0.783

rps2

0.773

ssb

0.769

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
dnajc2	drg1	ENSTRUP00000065703	ENSTRUP00000024921	DnaJ (Hsp40) homolog, subfamily C, member 2.	Developmentally regulated GTP binding protein 1.	0.429
dnajc2	fau	ENSTRUP00000065703	ENSTRUP00000029977	DnaJ (Hsp40) homolog, subfamily C, member 2.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.435
dnajc2	rpl23a	ENSTRUP00000065703	ENSTRUP00000068150	DnaJ (Hsp40) homolog, subfamily C, member 2.	Ribosomal protein L23a; Belongs to the universal ribosomal protein uL23 family.	0.440
dnajc2	ssb	ENSTRUP00000065703	ENSTRUP00000045727	DnaJ (Hsp40) homolog, subfamily C, member 2.	Small RNA binding exonuclease protection factor La.	0.633
dnajc2	zc3h15	ENSTRUP00000065703	ENSTRUP00000011947	DnaJ (Hsp40) homolog, subfamily C, member 2.	Zinc finger CCCH-type containing 15.	0.803
drg1	dnajc2	ENSTRUP00000024921	ENSTRUP00000065703	Developmentally regulated GTP binding protein 1.	DnaJ (Hsp40) homolog, subfamily C, member 2.	0.429
drg1	drg2	ENSTRUP00000024921	ENSTRUP00000053307	Developmentally regulated GTP binding protein 1.	Developmentally regulated GTP binding protein 2.	0.690
drg1	fau	ENSTRUP00000024921	ENSTRUP00000029977	Developmentally regulated GTP binding protein 1.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.753
drg1	rpl23a	ENSTRUP00000024921	ENSTRUP00000068150	Developmentally regulated GTP binding protein 1.	Ribosomal protein L23a; Belongs to the universal ribosomal protein uL23 family.	0.860
drg1	rps12	ENSTRUP00000024921	ENSTRUP00000011645	Developmentally regulated GTP binding protein 1.	40S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family.	0.717
drg1	rps15	ENSTRUP00000024921	ENSTRUP00000086995	Developmentally regulated GTP binding protein 1.	Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.761
drg1	rps2	ENSTRUP00000024921	ENSTRUP00000016765	Developmentally regulated GTP binding protein 1.	Ribosomal protein S2; Belongs to the universal ribosomal protein uS5 family.	0.772
drg1	rwdd1	ENSTRUP00000024921	ENSTRUP00000080221	Developmentally regulated GTP binding protein 1.	RWD domain containing 1.	0.942
drg1	zc3h15	ENSTRUP00000024921	ENSTRUP00000011947	Developmentally regulated GTP binding protein 1.	Zinc finger CCCH-type containing 15.	0.993
drg2	drg1	ENSTRUP00000053307	ENSTRUP00000024921	Developmentally regulated GTP binding protein 2.	Developmentally regulated GTP binding protein 1.	0.690
drg2	fau	ENSTRUP00000053307	ENSTRUP00000029977	Developmentally regulated GTP binding protein 2.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.750
drg2	rpl23a	ENSTRUP00000053307	ENSTRUP00000068150	Developmentally regulated GTP binding protein 2.	Ribosomal protein L23a; Belongs to the universal ribosomal protein uL23 family.	0.620
drg2	rps12	ENSTRUP00000053307	ENSTRUP00000011645	Developmentally regulated GTP binding protein 2.	40S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family.	0.630
drg2	rps15	ENSTRUP00000053307	ENSTRUP00000086995	Developmentally regulated GTP binding protein 2.	Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.721
drg2	rps2	ENSTRUP00000053307	ENSTRUP00000016765	Developmentally regulated GTP binding protein 2.	Ribosomal protein S2; Belongs to the universal ribosomal protein uS5 family.	0.724

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

42

average node degree:

7.64

avg. local clustering coefficient:

0.908

expected number of edges:

10

PPI enrichment p-value:

9.44e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006011

UDP-glucose metabolic process

2 of 2

2.27

0.91

0.0211

GO:0009225

Nucleotide-sugar metabolic process

3 of 12

1.66

0.89

0.0160

GO:0005975

Carbohydrate metabolic process

8 of 163

0.96

0.87

0.00026

GO:0000271

Polysaccharide biosynthetic process

4 of 35

1.32

0.78

0.0160

GO:0005978

Glycogen biosynthetic process

2 of 4

1.97

0.78

0.0331

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016779

Nucleotidyltransferase activity

5 of 42

1.34

1.14

0.0012

GO:0008878

glucose-1-phosphate adenylyltransferase activity

2 of 2

2.27

0.75

0.0421

GO:0003983

UTP:glucose-1-phosphate uridylyltransferase activity

2 of 2

2.27

0.75

0.0421

GO:0004645

1,4-alpha-oligoglucan phosphorylase activity

2 of 3

2.09

0.74

0.0421

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031470

Carboxysome

2 of 2

2.27

0.98

0.0154

GO:0045121

Membrane raft

2 of 5

1.87

0.91

0.0178

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2250

Starch and sucrose metabolism, and Alpha-amylase domain

6 of 24

1.66

2.32

1.22e-06

CL:2282

Glycogen metabolic process

3 of 5

2.04

1.71

0.00043

CL:2034

Mixed, incl. Carbohydrate transport, and Microbial metabolism in diverse environments

7 of 132

0.99

0.94

0.00014

CL:2032

Carbohydrate transport, and Carbohydrate metabolic process

8 of 166

0.95

0.91

7.39e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lagl00500

Starch and sucrose metabolism

7 of 26

1.7

3.01

4.31e-09

lagl00520

Amino sugar and nucleotide sugar metabolism

6 of 26

1.63

2.48

1.84e-07

lagl00052

Galactose metabolism

4 of 10

1.87

2.23

1.38e-05

lagl00541

O-Antigen nucleotide sugar biosynthesis

4 of 11

1.83

2.19

1.41e-05

lagl00040

Pentose and glucuronate interconversions

2 of 3

2.09

1.29

0.0035

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0010170

glucose-1-phosphate adenylyltransferase complex

2 of 2

2.27

0.8

0.0331

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0548

Nucleotidyltransferase

5 of 26

1.55

1.73

4.38e-05

KW-0119

Carbohydrate metabolism

3 of 14

1.6

1.03

0.0066

KW-0808

Transferase

7 of 240

0.73

0.52

0.0066

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12804

MobA-like NTP transferase domain

4 of 5

2.17

2.39

1.90e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005835

Nucleotidyl transferase domain

5 of 5

2.27

3.26

3.06e-07

IPR029044

Nucleotide-diphospho-sugar transferases

5 of 21

1.64

1.85

3.84e-05

IPR011832

Glucose-1-phosphate adenylyltransferase, GlgD subunit

2 of 2

2.27

0.76

0.0411

IPR011831

Glucose-1-phosphate adenylyltransferase

2 of 2

2.27

0.76

0.0411

IPR005771

UTP--glucose-1-phosphate uridylyltransferase, bacterial/archaeal-type

2 of 2

2.27

0.76

0.0411

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