Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
hsd17b8Hydroxysteroid (17-beta) dehydrogenase 8. (280 aa)    
Predicted Functional Partners:
cbr4
Carbonyl reductase 4.
  
0.999
hsd17b3
Hydroxysteroid (17-beta) dehydrogenase 3.
 
 
 0.964
OXSM
3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
 0.955
hsd11b1l
Hydroxysteroid (11-beta) dehydrogenase 1-like a.
  
  
 0.937
LOC101073188
Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family.
   
 
 0.935
cyp17a2
Uncharacterized protein; Belongs to the cytochrome P450 family.
   
 
 0.935
cyp17a1
Uncharacterized protein; Belongs to the cytochrome P450 family.
   
 
 0.935
pfcyp19a
Uncharacterized protein; Belongs to the cytochrome P450 family.
   
 
 0.929
srd5a3
Steroid 5 alpha-reductase 3.
     
 0.928
srd5a1
3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
   
 
 0.927
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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