UPF1 protein (Takifugu rubripes) - STRING interaction network

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UPF1

Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity). (1118 aa)

Predicted Functional Partners:

UPF2

0.998

smg1

0.995

upf3b

0.990

upf3a

0.980

smg5

0.954

smg6

0.952

rbm8a

0.946

dcp1a

0.924

rnps1

0.903

LOC101064659

0.900

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101064659	UPF1	ENSTRUP00000000308	ENSTRUP00000012294	Uncharacterized protein.	Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).	0.900
LOC101064659	UPF2	ENSTRUP00000000308	ENSTRUP00000018623	Uncharacterized protein.	UPF2 regulator of nonsense mediated mRNA decay.	0.998
LOC101064659	dcp1a	ENSTRUP00000000308	ENSTRUP00000008058	Uncharacterized protein.	Decapping mRNA 1A.	0.924
LOC101064659	rbm8a	ENSTRUP00000000308	ENSTRUP00000033509	Uncharacterized protein.	RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.	0.946
LOC101064659	rnps1	ENSTRUP00000000308	ENSTRUP00000021579	Uncharacterized protein.	RNA binding protein S1, serine-rich domain.	0.909
LOC101064659	smg1	ENSTRUP00000000308	ENSTRUP00000065898	Uncharacterized protein.	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family.	0.996
LOC101064659	smg5	ENSTRUP00000000308	ENSTRUP00000031846	Uncharacterized protein.	SMG5 nonsense mediated mRNA decay factor.	0.954
LOC101064659	smg6	ENSTRUP00000000308	ENSTRUP00000077418	Uncharacterized protein.	SMG6 nonsense mediated mRNA decay factor.	0.952
LOC101064659	upf3a	ENSTRUP00000000308	ENSTRUP00000073483	Uncharacterized protein.	UPF3A regulator of nonsense mediated mRNA decay.	0.980
LOC101064659	upf3b	ENSTRUP00000000308	ENSTRUP00000026872	Uncharacterized protein.	UPF3B regulator of nonsense mediated mRNA decay.	0.990
UPF1	LOC101064659	ENSTRUP00000012294	ENSTRUP00000000308	Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).	Uncharacterized protein.	0.900
UPF1	UPF2	ENSTRUP00000012294	ENSTRUP00000018623	Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).	UPF2 regulator of nonsense mediated mRNA decay.	0.998
UPF1	dcp1a	ENSTRUP00000012294	ENSTRUP00000008058	Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).	Decapping mRNA 1A.	0.924
UPF1	rbm8a	ENSTRUP00000012294	ENSTRUP00000033509	Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).	RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.	0.946
UPF1	rnps1	ENSTRUP00000012294	ENSTRUP00000021579	Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).	RNA binding protein S1, serine-rich domain.	0.903
UPF1	smg1	ENSTRUP00000012294	ENSTRUP00000065898	Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family.	0.995
UPF1	smg5	ENSTRUP00000012294	ENSTRUP00000031846	Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).	SMG5 nonsense mediated mRNA decay factor.	0.954
UPF1	smg6	ENSTRUP00000012294	ENSTRUP00000077418	Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).	SMG6 nonsense mediated mRNA decay factor.	0.952
UPF1	upf3a	ENSTRUP00000012294	ENSTRUP00000073483	Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).	UPF3A regulator of nonsense mediated mRNA decay.	0.980
UPF1	upf3b	ENSTRUP00000012294	ENSTRUP00000026872	Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).	UPF3B regulator of nonsense mediated mRNA decay.	0.990

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