UPF1 protein (Takifugu rubripes) - STRING interaction network

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UPF1

Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity). (1118 aa)

Predicted Functional Partners:

UPF2

0.998

smg1

0.997

upf3b

0.993

smg6

0.991

smg5

0.990

upf3a

0.983

dcp1a

0.973

eif4a3

0.971

rbm8a

0.966

ncbp2

0.960

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
UPF1	UPF2	ENSTRUP00000012294	ENSTRUP00000018623	Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).	UPF2 regulator of nonsense mediated mRNA decay.	0.998
UPF1	dcp1a	ENSTRUP00000012294	ENSTRUP00000008058	Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).	Decapping mRNA 1A.	0.973
UPF1	eif4a3	ENSTRUP00000012294	ENSTRUP00000029160	Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).	Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family.	0.971
UPF1	ncbp2	ENSTRUP00000012294	ENSTRUP00000075961	Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...]	0.960
UPF1	rbm8a	ENSTRUP00000012294	ENSTRUP00000033509	Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).	RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.	0.966
UPF1	smg1	ENSTRUP00000012294	ENSTRUP00000065898	Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family.	0.997
UPF1	smg5	ENSTRUP00000012294	ENSTRUP00000031846	Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).	SMG5 nonsense mediated mRNA decay factor.	0.990
UPF1	smg6	ENSTRUP00000012294	ENSTRUP00000077418	Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).	SMG6 nonsense mediated mRNA decay factor.	0.991
UPF1	upf3a	ENSTRUP00000012294	ENSTRUP00000073483	Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).	UPF3A regulator of nonsense mediated mRNA decay.	0.983
UPF1	upf3b	ENSTRUP00000012294	ENSTRUP00000026872	Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).	UPF3B regulator of nonsense mediated mRNA decay.	0.993
UPF2	UPF1	ENSTRUP00000018623	ENSTRUP00000012294	UPF2 regulator of nonsense mediated mRNA decay.	Putative regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an rent1-rent2-rent3 surveillance complex is believed to activate NMD (By similarity).	0.998
UPF2	dcp1a	ENSTRUP00000018623	ENSTRUP00000008058	UPF2 regulator of nonsense mediated mRNA decay.	Decapping mRNA 1A.	0.737
UPF2	eif4a3	ENSTRUP00000018623	ENSTRUP00000029160	UPF2 regulator of nonsense mediated mRNA decay.	Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family.	0.981
UPF2	ncbp2	ENSTRUP00000018623	ENSTRUP00000075961	UPF2 regulator of nonsense mediated mRNA decay.	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...]	0.791
UPF2	rbm8a	ENSTRUP00000018623	ENSTRUP00000033509	UPF2 regulator of nonsense mediated mRNA decay.	RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.	0.995
UPF2	smg1	ENSTRUP00000018623	ENSTRUP00000065898	UPF2 regulator of nonsense mediated mRNA decay.	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family.	0.996
UPF2	smg5	ENSTRUP00000018623	ENSTRUP00000031846	UPF2 regulator of nonsense mediated mRNA decay.	SMG5 nonsense mediated mRNA decay factor.	0.976
UPF2	smg6	ENSTRUP00000018623	ENSTRUP00000077418	UPF2 regulator of nonsense mediated mRNA decay.	SMG6 nonsense mediated mRNA decay factor.	0.976
UPF2	upf3a	ENSTRUP00000018623	ENSTRUP00000073483	UPF2 regulator of nonsense mediated mRNA decay.	UPF3A regulator of nonsense mediated mRNA decay.	0.994
UPF2	upf3b	ENSTRUP00000018623	ENSTRUP00000026872	UPF2 regulator of nonsense mediated mRNA decay.	UPF3B regulator of nonsense mediated mRNA decay.	0.999

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