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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NPC1L1SSD domain-containing protein. (1353 aa)    
Predicted Functional Partners:
npc2
Niemann-Pick disease, type C2.
   
 0.947
srebf1
Sterol regulatory element binding transcription factor 1.
   
 0.879
srebf2
Sterol regulatory element binding transcription factor 2.
   
 0.838
LOC101071379
MYCN proto-oncogene, bHLH transcription factor.
   
 0.793
insig1
Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis.
   
 0.674
insig2
Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.
   
 0.670
mbtps1
Membrane-bound transcription factor peptidase, site 1.
   
 
 0.541
abcg5
ATP-binding cassette, sub-family G (WHITE), member 5.
   
 
 0.463
slc27a4
Solute carrier family 27 member 4.
   
  
 0.443
nr1h4
Nuclear receptor subfamily 1, group H, member 4.
   
  
 0.442
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.