STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
e4f1E4F transcription factor 1. (793 aa)    
Predicted Functional Partners:
LOC101079595
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 0.707
wdr24
WD repeat domain 24.
   
 
  0.662
anks3
Ankyrin repeat and sterile alpha motif domain containing 3.
   
  0.662
Brat1
Uncharacterized protein.
   
    0.625
zgpat
Zinc finger, CCCH-type with G patch domain.
   
   0.621
mms19
MMS19 homolog, cytosolic iron-sulfur assembly component.
    
 
 0.569
asl
Argininosuccinate lyase.
      
 0.552
smarca4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4a.
    
 0.502
perp
P53 apoptosis effector related to pmp22.
      
 0.497
telo2
TEL2, telomere maintenance 2, homolog (S. cerevisiae).
   
    0.489
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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