Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
paf1PAF1 homolog, Paf1/RNA polymerase II complex component. (530 aa)    
Predicted Functional Partners:
leo1
LEO1 homolog, Paf1/RNA polymerase II complex component.
   
 0.999
cdc73
Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae).
   
 0.999
wdr61
WD repeat domain 61.
   
 0.999
ctr9
CTR9 homolog, Paf1/RNA polymerase II complex component.
   
 0.999
rtf1
RTF1 homolog, Paf1/RNA polymerase II complex component.
   
 0.998
LOC101068554
SPT16 homolog, facilitates chromatin remodeling subunit.
    
 0.977
ssrp1
FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]
   
 0.968
polr2a
DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 0.957
cinp
Cyclin-dependent kinase 2 interacting protein.
   
 0.941
cdk9
Cyclin-dependent kinase 9 (CDC2-related kinase); Belongs to the protein kinase superfamily.
   
 0.902
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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