Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
tnfaTumor necrosis factor alpha. (250 aa)    
Predicted Functional Partners:
tnfrsf1a
Tumor necrosis factor receptor superfamily member 1A.
    
 0.974
tnfrsf1a-2
Tumor necrosis factor receptor superfamily, member 1a.
    
 0.974
LOC101077059
Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.
   
 0.922
tnfrsf14
Tumor necrosis factor receptor superfamily, member 1B.
  
  
 0.921
nfkb1
Nuclear factor NF-kappa-B p105 subunit.
   
 0.915
c-JunL
C-JunL protein; Belongs to the bZIP family.
   
 0.906
LOC101073743
V-rel avian reticuloendotheliosis viral oncogene homolog A.
     
 0.902
il1b
Interleukin-1; Belongs to the IL-1 family.
   
  
 0.879
il10
Interleukin 10.
   
  
 0.757
il-6
Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.
      
 0.701
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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