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Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
htr1a-B5-hydroxytryptamine receptor 1A-beta; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium se [...] (416 aa)    
Predicted Functional Partners:
GNG4
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4.
    
  0.796
gng2
Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
    
  0.796
gnb1
Guanine nucleotide binding protein (G protein), beta polypeptide 1a.
    
  0.788
gnb4
Guanine nucleotide binding protein (G protein), beta polypeptide 4b.
    
  0.788
gnb2
Guanine nucleotide binding protein (G protein), beta polypeptide 2.
    
  0.788
LOC101077498
Guanine nucleotide binding protein (G protein), beta 5b.
    
  0.771
LOC101069051
Guanine nucleotide binding protein (G protein), beta polypeptide 3a.
    
  0.771
LOC101074575
Guanine nucleotide binding protein (G protein), beta 5a.
    
  0.771
LOC101062666
Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
   
  0.766
LOC101061293
Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b.
    
 0.764
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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