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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
twist2BHLH domain-containing protein. (164 aa)    
Predicted Functional Partners:
LOC101079595
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 
 0.528
foxn4
Forkhead box N4.
   
 
 0.454
tbx15
T-box transcription factor 15.
   
  
 0.451
setd2
SET domain containing 2, histone lysine methyltransferase.
   
 
 0.441
LOC101079401
Transcription factor 3a.
    
 
 0.421
tcf3
Transcription factor 3b.
    
 
 0.421
tcf12
Transcription factor 12.
    
 
 0.421
TCF4
Transcription factor 4.
    
 
 0.421
LOC101072332
Transcription factor 12-like.
    
 
 0.420
LOC101076120
Cytochrome P450, family 26, subfamily b, polypeptide 1; Belongs to the cytochrome P450 family.
   
  
 0.402
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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