LOC101064284 protein (Takifugu rubripes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LOC101064284

Protocadherin 7a. (1370 aa)

Predicted Functional Partners:

LOC101062065

0.446

LOC101069918

0.404

aplp2

0.402

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101062065	LOC101064284	ENSTRUP00000021919	ENSTRUP00000014942	Zgc:110783.	Protocadherin 7a.	0.446
LOC101064284	LOC101062065	ENSTRUP00000014942	ENSTRUP00000021919	Protocadherin 7a.	Zgc:110783.	0.446
LOC101064284	LOC101069918	ENSTRUP00000014942	ENSTRUP00000072735	Protocadherin 7a.	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.404
LOC101064284	aplp2	ENSTRUP00000014942	ENSTRUP00000059205	Protocadherin 7a.	Amyloid beta (A4) precursor-like protein 2.	0.402
LOC101069918	LOC101064284	ENSTRUP00000072735	ENSTRUP00000014942	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	Protocadherin 7a.	0.404
aplp2	LOC101064284	ENSTRUP00000059205	ENSTRUP00000014942	Amyloid beta (A4) precursor-like protein 2.	Protocadherin 7a.	0.402

Network Stats

number of nodes:

11

number of edges:

18

average node degree:

3.27

avg. local clustering coefficient:

0.871

expected number of edges:

12

PPI enrichment p-value:

0.0535

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005986

Sucrose biosynthetic process

2 of 2

3.28

1.07

0.0121

GO:0006002

Fructose 6-phosphate metabolic process

2 of 9

2.62

1.05

0.0125

GO:0030388

Fructose 1,6-bisphosphate metabolic process

2 of 11

2.54

1.04

0.0125

GO:0006000

Fructose metabolic process

2 of 11

2.54

1.04

0.0125

GO:0036158

Outer dynein arm assembly

2 of 14

2.43

1.02

0.0134

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0047617

acyl-CoA hydrolase activity

3 of 24

2.37

1.65

0.00084

GO:0042132

Fructose 1,6-bisphosphate 1-phosphatase activity

2 of 2

3.28

1.6

0.0013

GO:0004784

Superoxide dismutase activity

2 of 3

3.1

1.58

0.0014

GO:0045504

Dynein heavy chain binding

2 of 15

2.4

1.03

0.0129

GO:0005507

Copper ion binding

2 of 38

2.0

0.71

0.0468

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030286

Dynein complex

3 of 56

2.01

1.22

0.0044

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3046

Dynein heavy chain binding, and Dynein light chain type 1

3 of 5

3.05

2.52

2.69e-05

CL:34035

Acyl-CoA thioesterase, long chain, and Thioesterase domain

3 of 7

2.91

2.49

2.88e-05

CL:24468

Superoxide dismutase activity, and Regulation of oxidative phosphorylation uncoupler activity

2 of 5

2.88

1.37

0.0033

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00062

Fatty acid elongation

3 of 51

2.05

1.67

0.00052

map01040

Biosynthesis of unsaturated fatty acids

3 of 63

1.95

1.64

0.00052

map00051

Fructose and mannose metabolism

2 of 63

1.78

0.82

0.0258

map00030

Pentose phosphate pathway

2 of 55

1.84

0.82

0.0258

map00010

Glycolysis / Gluconeogenesis

2 of 99

1.58

0.66

0.0484

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0036157

Outer dynein arm

2 of 4

2.98

1.33

0.0040

GOCC:0030286

Dynein complex

3 of 51

2.05

1.25

0.0040

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0186

Copper

2 of 9

2.62

1.28

0.0046

KW-0119

Carbohydrate metabolism

2 of 33

2.06

0.86

0.0246

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00316

Fructose-1-6-bisphosphatase, N-terminal domain

2 of 2

3.28

1.38

0.0033

PF00080

Copper/zinc superoxide dismutase (SODC)

2 of 3

3.1

1.38

0.0033

PF08840

BAAT / Acyl-CoA thioester hydrolase C terminal

2 of 4

2.98

1.37

0.0033

PF04775

Acyl-CoA thioester hydrolase/BAAT N-terminal region

2 of 8

2.67

1.21

0.0062

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR044015

Fructose-1-6-bisphosphatase class 1, C-terminal

2 of 2

3.28

1.1

0.0106

IPR036423

Superoxide dismutase-like, copper/zinc binding domain superfamily

2 of 3

3.1

1.1

0.0106

IPR033391

Fructose-1-6-bisphosphatase class I, N-terminal

2 of 2

3.28

1.1

0.0106

IPR028343

Fructose-1,6-bisphosphatase

2 of 2

3.28

1.1

0.0106

IPR024134

Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone

2 of 3

3.1

1.1

0.0106

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (26%) [HD]

Permalink

Network

Cooccurrence

Experiments

Neighborhood

Databases

Fusion

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About