Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
smpdl3bAcid sphingomyelinase-like phosphodiesterase. (441 aa)    
Predicted Functional Partners:
tmem259
Transmembrane protein 259.
      
 0.732
cachd1
Cache domain containing 1.
      
 0.725
LOC101069957
Family with sequence similarity 131 member C.
      
 0.723
dhrs7c
Dehydrogenase/reductase (SDR family) member 7Cb.
      
 0.710
smpd2
Sphingomyelin phosphodiesterase 2b, neutral membrane (neutral sphingomyelinase).
      
 0.695
selenoi
Selenoprotein I; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
      
 0.659
sh3rf1
SH3 domain containing ring finger 1.
      
 0.638
actr6
Actin related protein 6; Belongs to the actin family.
      
 0.630
mrps11
Mitochondrial ribosomal protein S11; Belongs to the universal ribosomal protein uS11 family.
      
 0.627
mrpl35
Mitochondrial ribosomal protein L35.
      
 0.626
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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