Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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[Homology]
Score
frkTyrosine-protein kinase. (515 aa)    
Predicted Functional Partners:
Mipol1
Mirror-image polydactyly gene 1 protein isoform X1.
   
    0.953
kiaa1328
Zgc:162344.
   
    0.837
LOC101074730
Transmembrane phosphatase with tensin homology.
    
 0.765
pten
Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.
    
 0.765
LOC101071277
SH2 domain-containing protein.
   
 0.736
rapgef1
Rap guanine nucleotide exchange factor (GEF) 1b.
    
 0.722
sh2d1a
SH2 domain containing 1A duplicate b.
   
 0.704
nedd9
Neural precursor cell expressed, developmentally down-regulated 9.
    
 0.689
LOC101071528
Macrophage stimulating 1 receptor a.
   
  0.682
mst1r
Macrophage stimulating 1 receptor b.
   
  0.682
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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