topbp1 protein (Takifugu rubripes) - STRING interaction network

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Score

topbp1

DNA topoisomerase II binding protein 1. (1496 aa)

Predicted Functional Partners:

rhno1

0.996

atrip

0.995

ticrr

0.994

brip1

0.994

brca1

0.993

atr

0.991

CLSPN

0.990

bard1

0.989

chek1

0.974

LOC101079595

0.973

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLSPN	atr	ENSTRUP00000021610	ENSTRUP00000035419	Claspin.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.959
CLSPN	atrip	ENSTRUP00000021610	ENSTRUP00000008639	Claspin.	Uncharacterized protein.	0.875
CLSPN	bard1	ENSTRUP00000021610	ENSTRUP00000037470	Claspin.	BRCA1 associated RING domain 1.	0.831
CLSPN	brca1	ENSTRUP00000021610	ENSTRUP00000050269	Claspin.	Uncharacterized protein.	0.943
CLSPN	brip1	ENSTRUP00000021610	ENSTRUP00000084791	Claspin.	BRCA1 interacting protein C-terminal helicase 1.	0.742
CLSPN	chek1	ENSTRUP00000021610	ENSTRUP00000043876	Claspin.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.997
CLSPN	rhno1	ENSTRUP00000021610	ENSTRUP00000054653	Claspin.	Si:ch73-352p4.5.	0.901
CLSPN	ticrr	ENSTRUP00000021610	ENSTRUP00000039544	Claspin.	Treslin_N domain-containing protein.	0.643
CLSPN	topbp1	ENSTRUP00000021610	ENSTRUP00000016012	Claspin.	DNA topoisomerase II binding protein 1.	0.990
LOC101079595	atr	ENSTRUP00000030644	ENSTRUP00000035419	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.998
LOC101079595	atrip	ENSTRUP00000030644	ENSTRUP00000008639	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Uncharacterized protein.	0.711
LOC101079595	bard1	ENSTRUP00000030644	ENSTRUP00000037470	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	BRCA1 associated RING domain 1.	0.980
LOC101079595	brca1	ENSTRUP00000030644	ENSTRUP00000050269	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Uncharacterized protein.	0.995
LOC101079595	brip1	ENSTRUP00000030644	ENSTRUP00000084791	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	BRCA1 interacting protein C-terminal helicase 1.	0.547
LOC101079595	chek1	ENSTRUP00000030644	ENSTRUP00000043876	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.999
LOC101079595	rhno1	ENSTRUP00000030644	ENSTRUP00000054653	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Si:ch73-352p4.5.	0.531
LOC101079595	topbp1	ENSTRUP00000030644	ENSTRUP00000016012	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	DNA topoisomerase II binding protein 1.	0.973
atr	CLSPN	ENSTRUP00000035419	ENSTRUP00000021610	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Claspin.	0.959
atr	LOC101079595	ENSTRUP00000035419	ENSTRUP00000030644	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.998
atr	atrip	ENSTRUP00000035419	ENSTRUP00000008639	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.999