Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1098 aa)    
Predicted Functional Partners:
pdpk1
3-phosphoinositide dependent protein kinase 1b.
    
 0.975
mtor
Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.
    
0.965
pten
Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.
   
 0.955
hras
HRas proto-oncogene, GTPase a.
   
 0.953
kdr
Kinase insert domain receptor (a type III receptor tyrosine kinase); Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    
 0.953
pgr
Progesterone receptor.
   
 0.922
pik3r5
Phosphoinositide-3-kinase, regulatory subunit 5.
   
 0.920
LOC101063692
Phosphoinositide-3-kinase, regulatory subunit 2 (beta).
   
 0.900
LOC101065244
Uncharacterized protein.
   
 0.900
pik3r3
Phosphoinositide-3-kinase, regulatory subunit 3b (gamma).
   
 0.900
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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