Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ppargc1aPeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (1306 aa)    
Predicted Functional Partners:
esrra
Estrogen-related receptor alpha.
   
 0.994
LOC101072628
Forkhead box O1 a.
    
 0.965
sirt1
Sirtuin 1.
   
 0.961
LOC101073915
Fork-head domain-containing protein.
    
 0.953
nrf1
Nuclear respiratory factor 1.
    
 0.933
PPARA
Uncharacterized protein.
    
 0.926
pparg
Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]
    
 0.926
LOC101062852
Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor).
    
 0.912
ENSTRUP00000039664
CWC15 spliceosome associated protein homolog.
   
 
 0.905
crnkl1
Crooked neck pre-mRNA splicing factor 1.
   
 0.890
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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