IER5L protein (Takifugu rubripes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

IER5L

Immediate early response 5-like. (295 aa)

Predicted Functional Partners:

ENSTRUP00000048396

0.723

get3

0.707

dusp10

0.700

socs2

0.700

ENSTRUP00000085642

0.700

phax

0.699

tm9sf4

0.697

naa25

0.677

sgta

0.519

sgtb

0.519

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSTRUP00000048396	IER5L	ENSTRUP00000048396	ENSTRUP00000017948	DUF4585 domain-containing protein.	Immediate early response 5-like.	0.723
ENSTRUP00000048396	tm9sf4	ENSTRUP00000048396	ENSTRUP00000007463	DUF4585 domain-containing protein.	Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.	0.654
ENSTRUP00000085642	IER5L	ENSTRUP00000085642	ENSTRUP00000017948	Suppressor of cytokine signaling 2.	Immediate early response 5-like.	0.700
ENSTRUP00000085642	dusp10	ENSTRUP00000085642	ENSTRUP00000056038	Suppressor of cytokine signaling 2.	Dual specificity phosphatase 10.	0.692
ENSTRUP00000085642	socs2	ENSTRUP00000085642	ENSTRUP00000078432	Suppressor of cytokine signaling 2.	Suppressor of cytokine signaling 2.	0.544
IER5L	ENSTRUP00000048396	ENSTRUP00000017948	ENSTRUP00000048396	Immediate early response 5-like.	DUF4585 domain-containing protein.	0.723
IER5L	ENSTRUP00000085642	ENSTRUP00000017948	ENSTRUP00000085642	Immediate early response 5-like.	Suppressor of cytokine signaling 2.	0.700
IER5L	dusp10	ENSTRUP00000017948	ENSTRUP00000056038	Immediate early response 5-like.	Dual specificity phosphatase 10.	0.700
IER5L	get3	ENSTRUP00000017948	ENSTRUP00000016528	Immediate early response 5-like.	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	0.707
IER5L	naa25	ENSTRUP00000017948	ENSTRUP00000066293	Immediate early response 5-like.	N(alpha)-acetyltransferase 25, NatB auxiliary subunit.	0.677
IER5L	phax	ENSTRUP00000017948	ENSTRUP00000004867	Immediate early response 5-like.	Phosphorylated adaptor for RNA export.	0.699
IER5L	sgta	ENSTRUP00000017948	ENSTRUP00000029013	Immediate early response 5-like.	Small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha.	0.519
IER5L	sgtb	ENSTRUP00000017948	ENSTRUP00000069166	Immediate early response 5-like.	Small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta.	0.519
IER5L	socs2	ENSTRUP00000017948	ENSTRUP00000078432	Immediate early response 5-like.	Suppressor of cytokine signaling 2.	0.700
IER5L	tm9sf4	ENSTRUP00000017948	ENSTRUP00000007463	Immediate early response 5-like.	Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.	0.697
dusp10	ENSTRUP00000085642	ENSTRUP00000056038	ENSTRUP00000085642	Dual specificity phosphatase 10.	Suppressor of cytokine signaling 2.	0.692
dusp10	IER5L	ENSTRUP00000056038	ENSTRUP00000017948	Dual specificity phosphatase 10.	Immediate early response 5-like.	0.700
dusp10	socs2	ENSTRUP00000056038	ENSTRUP00000078432	Dual specificity phosphatase 10.	Suppressor of cytokine signaling 2.	0.692
get3	IER5L	ENSTRUP00000016528	ENSTRUP00000017948	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	Immediate early response 5-like.	0.707
get3	naa25	ENSTRUP00000016528	ENSTRUP00000066293	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	N(alpha)-acetyltransferase 25, NatB auxiliary subunit.	0.443