Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
appbp2Amyloid beta precursor protein (cytoplasmic tail) binding protein 2. (589 aa)    
Predicted Functional Partners:
cul2
Cullin 2; Belongs to the cullin family.
   
 0.939
cops3
COP9 signalosome subunit 3.
    
  0.918
cops2
COP9 signalosome subunit 2.
    
  0.909
eloc
Elongin C paralog a; Belongs to the SKP1 family.
   
 0.907
HPS6
HPS6 biogenesis of lysosomal organelles complex 2 subunit 3.
      
 0.880
mrpl28
Mitochondrial ribosomal protein L28.
    
   0.800
klhdc3
Kelch domain-containing protein 3 isoform X1.
      
 0.780
KLHDC2
Kelch domain containing 2.
      
 0.778
APP
Amyloid beta precursor protein.
   
 0.765
LOC101078447
Amyloid-beta A4 protein; Functional neuronal receptor which couples to intracellular signaling pathway through the GTP-binding protein G(O); Belongs to the APP family.
   
 0.765
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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