six3 protein (Takifugu rubripes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

six3

SIX homeobox 3a. (294 aa)

Predicted Functional Partners:

eya1

0.686

fzd4

0.660

pax6

0.574

eya3

0.573

LOC101079015

0.573

eya4

0.573

vax2

0.567

gbx1

0.545

LOC101073985

0.483

LOC101066273

0.482

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101066273	six3	ENSTRUP00000044310	ENSTRUP00000018341	ALX homeobox 4.	SIX homeobox 3a.	0.482
LOC101073985	six3	ENSTRUP00000084657	ENSTRUP00000018341	Orthodenticle homeobox 2a.	SIX homeobox 3a.	0.483
LOC101079015	eya3	ENSTRUP00000034935	ENSTRUP00000029556	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.470
LOC101079015	six3	ENSTRUP00000034935	ENSTRUP00000018341	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 3a.	0.573
eya1	eya3	ENSTRUP00000087800	ENSTRUP00000029556	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.473
eya1	six3	ENSTRUP00000087800	ENSTRUP00000018341	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 3a.	0.686
eya3	LOC101079015	ENSTRUP00000029556	ENSTRUP00000034935	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.470
eya3	eya1	ENSTRUP00000029556	ENSTRUP00000087800	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.473
eya3	eya4	ENSTRUP00000029556	ENSTRUP00000087636	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog 4; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity); B [...]	0.472
eya3	six3	ENSTRUP00000029556	ENSTRUP00000018341	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 3a.	0.573
eya4	eya3	ENSTRUP00000087636	ENSTRUP00000029556	Eyes absent homolog 4; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity); B [...]	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.472
eya4	six3	ENSTRUP00000087636	ENSTRUP00000018341	Eyes absent homolog 4; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity); B [...]	SIX homeobox 3a.	0.573
fzd4	six3	ENSTRUP00000015491	ENSTRUP00000018341	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	SIX homeobox 3a.	0.660
gbx1	six3	ENSTRUP00000013139	ENSTRUP00000018341	Gastrulation brain homeobox 1.	SIX homeobox 3a.	0.545
pax6	six3	ENSTRUP00000085114	ENSTRUP00000018341	Paired box 6b.	SIX homeobox 3a.	0.574
six3	LOC101066273	ENSTRUP00000018341	ENSTRUP00000044310	SIX homeobox 3a.	ALX homeobox 4.	0.482
six3	LOC101073985	ENSTRUP00000018341	ENSTRUP00000084657	SIX homeobox 3a.	Orthodenticle homeobox 2a.	0.483
six3	LOC101079015	ENSTRUP00000018341	ENSTRUP00000034935	SIX homeobox 3a.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.573
six3	eya1	ENSTRUP00000018341	ENSTRUP00000087800	SIX homeobox 3a.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.686
six3	eya3	ENSTRUP00000018341	ENSTRUP00000029556	SIX homeobox 3a.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.573