Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
plk4Polo-like kinase 4 (Drosophila). (915 aa)    
Predicted Functional Partners:
plk3
Serine/threonine-protein kinase PLK.
   
0.997
stil
STIL centriolar assembly protein.
   
 
 0.980
cep192
Centrosomal protein 192.
   
 0.973
ENSTRUP00000066839
annotation not available
   
 0.973
LOC101066249
Centromere protein J.
   
 0.964
espl1
Extra spindle pole bodies like 1, separase.
   
 0.963
fbxw11
F-box and WD repeat domain containing 11b.
    
 0.962
ENSTRUP00000087241
annotation not available
    
 0.958
bub1
BUB1 mitotic checkpoint serine/threonine kinase.
   
 0.950
mad2l1
MAD2 mitotic arrest deficient-like 1 (yeast).
   
 0.947
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
Server load: medium (44%) [HD]