Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
grnGranulin b. (669 aa)    
Predicted Functional Partners:
LOC101078112
Sortilin.
    
 
 0.756
LOC101073281
Sortilin.
    
 
 0.756
Glrx3
Glutaredoxin 3.
    
 
 0.647
dnajc10
DnaJ (Hsp40) homolog, subfamily C, member 10.
    
 
 0.601
LOC105418031
Surfactant protein Bb.
   
 0.597
psap
Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.
   
 0.597
LOC101070919
Cathepsin Bb; Belongs to the peptidase C1 family.
   
 0.594
LOC101076659
Cathepsin Ba; Belongs to the peptidase C1 family.
   
 0.594
lamp1
Lysosomal associated membrane protein 1a.
   
 
 0.584
cdk9
Cyclin-dependent kinase 9 (CDC2-related kinase); Belongs to the protein kinase superfamily.
    
   0.558
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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