Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
LOC101078759Pleckstrin homology domain containing, family O member 1b. (379 aa)    
Predicted Functional Partners:
SMURF2
E3 ubiquitin-protein ligase.
    
 
 0.649
LOC101071114
E3 ubiquitin-protein ligase.
    
 
 0.649
SMURF1
SMAD specific E3 ubiquitin protein ligase 1.
    
 
 0.649
capzb
F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
    
   0.570
vps45
Vacuolar protein sorting 45 homolog; Belongs to the STXBP/unc-18/SEC1 family.
 
    
 0.550
ccnb1
Cyclin B1; Belongs to the cyclin family.
    
   0.500
LOC101074416
Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.
    
   0.500
LOC101076205
Cyclin B2; Belongs to the cyclin family.
    
   0.500
LOC101065671
Cyclin N-terminal domain containing 2; Belongs to the cyclin family.
    
   0.500
LOC101068442
G2/mitotic-specific cyclin-B2-like.
    
   0.500
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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