Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
recql5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (1000 aa)    
Predicted Functional Partners:
polr2d
Polymerase (RNA) II (DNA directed) polypeptide D.
    
 
 0.973
polr2g
Polymerase (RNA) II (DNA directed) polypeptide G-like.
    
 
 0.973
Fancm
ERCC4 domain-containing protein.
   
 0.959
polr2a
DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.954
dna2
DNA replication helicase/nuclease 2.
   
 0.940
rad51
DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]
  
 0.935
polr2m
Uncharacterized protein.
    
   0.923
DXO
Decapping exoribonuclease.
   
   0.923
POLR2E
RNA polymerase II subunit E.
    
   0.916
polr2l
Polymerase (RNA) II (DNA directed) polypeptide L.
    
   0.896
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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