Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
dhx57DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57. (1236 aa)    
Predicted Functional Partners:
LOC101069505
40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Belongs to the universal ribosomal protein uS2 family.
   
 
 0.851
LOC101077791
Uncharacterized protein.
   
 0.806
mlst8
MTOR associated protein, LST8 homolog (S. cerevisiae).
      
 0.779
itsn1
Intersectin 1 (SH3 domain protein).
    
 0.776
ap2s1
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
    
 0.742
piwil1
Piwi-like RNA-mediated gene silencing 1; Belongs to the argonaute family.
   
 0.741
H2V528_TAKRU
Caprin-1_dimer domain-containing protein.
   
 
 0.735
ap2m1
AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]
   
 0.724
H2S6A2_TAKRU
PDZ domain-containing protein.
    
 0.716
rps2
Ribosomal protein S2; Belongs to the universal ribosomal protein uS5 family.
   
 0.705
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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