LOC101073658 protein (Takifugu rubripes) - STRING interaction network

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Score

LOC101073658

Guanylate cyclase. (1046 aa)

Predicted Functional Partners:

nudt2

0.905

entpd3

0.900

ITPA

0.900

nppa

0.826

nppc

0.816

pde5a

0.771

pde11a

0.756

LOC101061565

0.756

pde10a

0.756

pde6c

0.754

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ITPA	LOC101061565	ENSTRUP00000068546	ENSTRUP00000073128	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	Phosphodiesterase.	0.900
ITPA	LOC101073658	ENSTRUP00000068546	ENSTRUP00000020710	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	Guanylate cyclase.	0.900
ITPA	entpd3	ENSTRUP00000068546	ENSTRUP00000023436	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family.	0.908
ITPA	nudt2	ENSTRUP00000068546	ENSTRUP00000038655	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	Nudix (nucleoside diphosphate linked moiety X)-type motif 2.	0.934
ITPA	pde10a	ENSTRUP00000068546	ENSTRUP00000075591	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	Phosphodiesterase.	0.900
ITPA	pde11a	ENSTRUP00000068546	ENSTRUP00000044767	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (By similarity).	0.900
ITPA	pde5a	ENSTRUP00000068546	ENSTRUP00000079668	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	Phosphodiesterase.	0.904
ITPA	pde6c	ENSTRUP00000068546	ENSTRUP00000076919	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	Phosphodiesterase.	0.900
LOC101061565	ITPA	ENSTRUP00000073128	ENSTRUP00000068546	Phosphodiesterase.	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	0.900
LOC101061565	LOC101073658	ENSTRUP00000073128	ENSTRUP00000020710	Phosphodiesterase.	Guanylate cyclase.	0.756
LOC101061565	entpd3	ENSTRUP00000073128	ENSTRUP00000023436	Phosphodiesterase.	Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family.	0.900
LOC101061565	pde5a	ENSTRUP00000073128	ENSTRUP00000079668	Phosphodiesterase.	Phosphodiesterase.	0.722
LOC101073658	ITPA	ENSTRUP00000020710	ENSTRUP00000068546	Guanylate cyclase.	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	0.900
LOC101073658	LOC101061565	ENSTRUP00000020710	ENSTRUP00000073128	Guanylate cyclase.	Phosphodiesterase.	0.756
LOC101073658	entpd3	ENSTRUP00000020710	ENSTRUP00000023436	Guanylate cyclase.	Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family.	0.900
LOC101073658	nppa	ENSTRUP00000020710	ENSTRUP00000088156	Guanylate cyclase.	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Has a cGMP-stimulating activity (By similarity); Belongs to the natriuretic peptide family.	0.826
LOC101073658	nppc	ENSTRUP00000020710	ENSTRUP00000022021	Guanylate cyclase.	C-type natriuretic peptide 4; Exhibits natriuretic and vasodepressant activity. Has cGMP- stimulating activity. May help to regulate body fluid homeostasis in a variety of aquatic environments; Belongs to the natriuretic peptide family.	0.816
LOC101073658	nudt2	ENSTRUP00000020710	ENSTRUP00000038655	Guanylate cyclase.	Nudix (nucleoside diphosphate linked moiety X)-type motif 2.	0.905
LOC101073658	pde10a	ENSTRUP00000020710	ENSTRUP00000075591	Guanylate cyclase.	Phosphodiesterase.	0.756
LOC101073658	pde11a	ENSTRUP00000020710	ENSTRUP00000044767	Guanylate cyclase.	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (By similarity).	0.756