Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-expression
Experiments
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[Homology]
Score
chd7Chromodomain helicase DNA binding protein 7. (3247 aa)    
Predicted Functional Partners:
ctnnb1
Catenin (cadherin-associated protein), beta 1.
    
 0.769
LOC101068554
SPT16 homolog, facilitates chromatin remodeling subunit.
   
 
 0.712
ssrp1
FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]
    
 
 0.711
rtf1
RTF1 homolog, Paf1/RNA polymerase II complex component.
   
 
 0.706
leo1
LEO1 homolog, Paf1/RNA polymerase II complex component.
   
 
 0.706
LOC101070909
Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.
   
 0.691
LOC101074738
Retinoblastoma binding protein 5.
    
 
 0.685
ash2l
Ash2 like, histone lysine methyltransferase complex subunit.
    
 
 0.667
setd2
SET domain containing 2, histone lysine methyltransferase.
   
 0.619
LOC101063521-2
Histone H3.3.
    
 0.618
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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