Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
crhCorticotropin releasing hormone b. (167 aa)    
Predicted Functional Partners:
LOC101068283
Corticotropin releasing hormone receptor 1; Belongs to the G-protein coupled receptor 2 family.
    
 0.997
CRHR2
Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family.
    
 0.996
UCN
Urocortin 3, like.
    
 0.983
crhbp
Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.
   
 0.937
LOC101064982
Proopiomelanocortin.
   
 
 0.931
LOC101075851
Uncharacterized protein.
   
 0.889
TRH
Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
      
 0.803
LOC101076657
Neuropeptide Y.
   
  
 0.771
psmc1
Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family.
      
 0.743
LOC101073859
Isotocin-neurophysin IT 1; Isotocin causes contraction of smooth muscles; Belongs to the vasopressin/oxytocin family.
   
 
 0.742
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.