Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pgap1GPI inositol-deacylase isoform X1. (933 aa)    
Predicted Functional Partners:
mppe1
Metallophosphoesterase 1.
    
 0.968
pigt
Phosphatidylinositol glycan anchor biosynthesis, class T.
     
 0.960
pigk
GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family.
    
 0.958
gpaa1
Glycosylphosphatidylinositol anchor attachment 1.
     
 0.954
pigs
Phosphatidylinositol glycan anchor biosynthesis, class S.
    
 0.949
pgap3
Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation; Belongs to the PGAP3 family.
    
 0.948
pigu
Phosphatidylinositol glycan anchor biosynthesis, class U.
     
 0.934
pigg
Phosphatidylinositol glycan anchor biosynthesis class G.
   
 
 0.802
pigc
Phosphatidylinositol glycan anchor biosynthesis, class C.
      
 0.801
LOC101078401
Transmembrane emp24 domain-containing protein 10; Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side (By similarity).
    
 
 0.763
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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