Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LOC101077161HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a. (1507 aa)    
Predicted Functional Partners:
rps27a
Ribosomal protein S27a.
    
  0.751
LOC101079837
Angiomotin.
    
 0.722
uba52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
    
 0.707
gja1
Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
    
 0.687
wbp2
WW domain binding protein 2.
    
 
 0.684
LOC101079677
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
   
 0.662
sgk2
Non-specific serine/threonine protein kinase.
   
 0.662
SGK1
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
   
 0.662
LOC101074730
Transmembrane phosphatase with tensin homology.
    
 0.657
pten
Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.
    
 0.657
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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