herc2 protein (Takifugu rubripes) - STRING interaction network

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herc2

HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4823 aa)

Predicted Functional Partners:

rnf8

0.873

neurl4

0.794

brca1

0.791

UBE3A

0.766

LOC101079595

0.743

LOC101077614

0.713

mapk6

0.710

LOC101063160

0.672

usp16

0.659

bard1

0.646

Your Current Organism:

Takifugu rubripes

NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101063160	LOC101079595	ENSTRUP00000016582	ENSTRUP00000030644	Ubiquitin protein ligase E3A.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.905
LOC101063160	UBE3A	ENSTRUP00000016582	ENSTRUP00000060593	Ubiquitin protein ligase E3A.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.901
LOC101063160	herc2	ENSTRUP00000016582	ENSTRUP00000023760	Ubiquitin protein ligase E3A.	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	0.672
LOC101063160	mapk6	ENSTRUP00000016582	ENSTRUP00000057118	Ubiquitin protein ligase E3A.	Mitogen-activated protein kinase 6.	0.591
LOC101063160	neurl4	ENSTRUP00000016582	ENSTRUP00000031967	Ubiquitin protein ligase E3A.	Neuralized E3 ubiquitin protein ligase 4.	0.815
LOC101077614	LOC101079595	ENSTRUP00000079531	ENSTRUP00000030644	TPR_REGION domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.886
LOC101077614	herc2	ENSTRUP00000079531	ENSTRUP00000023760	TPR_REGION domain-containing protein.	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	0.713
LOC101079595	LOC101063160	ENSTRUP00000030644	ENSTRUP00000016582	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Ubiquitin protein ligase E3A.	0.905
LOC101079595	LOC101077614	ENSTRUP00000030644	ENSTRUP00000079531	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	TPR_REGION domain-containing protein.	0.886
LOC101079595	UBE3A	ENSTRUP00000030644	ENSTRUP00000060593	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.980
LOC101079595	bard1	ENSTRUP00000030644	ENSTRUP00000037470	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	BRCA1 associated RING domain 1.	0.980
LOC101079595	brca1	ENSTRUP00000030644	ENSTRUP00000050269	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Uncharacterized protein.	0.995
LOC101079595	herc2	ENSTRUP00000030644	ENSTRUP00000023760	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	0.743
LOC101079595	neurl4	ENSTRUP00000030644	ENSTRUP00000031967	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Neuralized E3 ubiquitin protein ligase 4.	0.637
UBE3A	LOC101063160	ENSTRUP00000060593	ENSTRUP00000016582	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	Ubiquitin protein ligase E3A.	0.901
UBE3A	LOC101079595	ENSTRUP00000060593	ENSTRUP00000030644	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.980
UBE3A	herc2	ENSTRUP00000060593	ENSTRUP00000023760	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	0.766
UBE3A	mapk6	ENSTRUP00000060593	ENSTRUP00000057118	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	Mitogen-activated protein kinase 6.	0.686
UBE3A	neurl4	ENSTRUP00000060593	ENSTRUP00000031967	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	Neuralized E3 ubiquitin protein ligase 4.	0.923
bard1	LOC101079595	ENSTRUP00000037470	ENSTRUP00000030644	BRCA1 associated RING domain 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.980